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Platensimycin

CAT: 0931-T35634-01Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0931-T35634-01Size:250 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
835876-32-9
Target
Others, Antibacterial, Antibiotic
Related Pathways
Microbiology/Virology, Others
Bioactivity
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM) . It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively) . By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance. PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.
Smiles
C[C@]12C[C@]34C[C@H]1C[C@H](O2)[C@H]3[C@](C)(CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)C(=O)C=C4
Molecular Formula
C24H27NO7
Molecular Weight
441.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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