PKSI-527

CAT: 0931-MF-0037826Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0037826Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
128837-71-8
Target
Others|||Serine Protease
Related Pathways
Others|||Proteases/Proteasome
Bioactivity
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 ?M) . It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 ?M, respectively) . PKSI-527 reduces bradykinin generation induced by kaolin and ?-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times.
Smiles
[C@@H](CC1=CC=CC=C1)(NC(=O)[C@H]2CC[C@H](CN)CC2)C(NC3=CC=C(CC(O)=O)C=C3)=O.Cl
Molecular Formula
C25H32ClN3O4
Molecular Weight
473.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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