Gallocyanine

• Target:

  Others|||Wnt/beta-catenin

• Related Pathways:

  Stem Cells|||Cytoskeletal Signaling|||Others

• Bioactivity:

  Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 ?M), thereby activating Wnt/?-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.

• Smiles:

  [Cl-].CN(C)c1ccc2nc3c(cc(O)c(O)c3[o+]c2c1)C(O)=O

• Molecular Formula:

  C15H13ClN2O5

• Molecular Weight:

  336.73

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1562-85-2