β-Rubromycin

• Target :

  Antibiotic|||Others|||Reverse Transcriptase|||HIV Protease

• Related Pathways :

  Microbiology/Virology|||Proteases/Proteasome|||Others

• Bioactivity :

  ?-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 ?M, respectively. ?-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 ?M. It also has antibacterial activity against Gram-positive bacteria. The structure of ?-rubromycin was originally described as containing an ortho-quinone group, but it was revised to a para-quinone group in 2000 using organic and biosynthetic methods, as well as spectroscopic analysis.1,2,3

• Smiles :

  COC(=O)c1cc2cc3CC[C@]4(CC5=C(O4)C(=O)c4c(O)c(OC)cc(OC)c4C5=O)Oc3c(O)c2c(=O)o1|c:13|

• Molecular Formula :

  C27H20O12

• Molecular Weight :

  536.445

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  27267-70-5