β-Rubromycin

CAT: 0931-T35428-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T35428-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

27267-70-5

Target

Antibiotic, Others, Reverse Transcriptase, HIV Protease

Related Pathways

Microbiology/Virology, Proteases/Proteasome, Others

Bioactivity

β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 μM. It also has antibacterial activity against Gram-positive bacteria. The structure of β-rubromycin was originally described as containing an ortho-quinone group, but it was revised to a para-quinone group in 2000 using organic and biosynthetic methods, as well as spectroscopic analysis.1,2,3

Smiles

COC(=O)c1cc2cc3CC[C@]4(CC5=C(O4)C(=O)c4c(O)c(OC)cc(OC)c4C5=O)Oc3c(O)c2c(=O)o1 |c:13|

Molecular Formula

C27H20O12

Molecular Weight

536.445

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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442620-01	Beta-Rubromycin discontinued. See 207089
207089-01	Rubromycin Beta (Methyl-8,10'-dihydroxy-5,7-dimethoxy-4,9,9'-trioxo-4,4',9,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate)

β-Rubromycin

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