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β-Rubromycin

CAT: 0931-T35428-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T35428-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
27267-70-5
Target
Antibiotic|||Others|||Reverse Transcriptase|||HIV Protease
Related Pathways
Microbiology/Virology|||Proteases/Proteasome|||Others
Bioactivity
?-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 ?M, respectively. ?-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 ?M. It also has antibacterial activity against Gram-positive bacteria. The structure of ?-rubromycin was originally described as containing an ortho-quinone group, but it was revised to a para-quinone group in 2000 using organic and biosynthetic methods, as well as spectroscopic analysis.1,2,3
Smiles
COC(=O)c1cc2cc3CC[C@]4(CC5=C(O4)C(=O)c4c(O)c(OC)cc(OC)c4C5=O)Oc3c(O)c2c(=O)o1|c:13|
Molecular Formula
C27H20O12
Molecular Weight
536.445
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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