β-Rubromycin

CAT: 0804-HY-122482Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122482Size:1 mg
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Description
β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a Ki of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC50 of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC50 values of 19.5 µM and 22.7 µM, respectively[1][2].
CAS Number
[27267-70-5]
UNSPSC
12352005
Hazard Statement
H302+H312-H319-H351
Target
Bacterial; HIV; Reverse Transcriptase; Telomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/β-rubromycin.html
Purity
97.7
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=C(C(O1)=CC(C=C(CC[C@@]2(OC(C3=O)=C(C(C4=C3C(O)=C(OC)C=C4OC)=O)C2)O5)C5=C6O)=C6C1=O)OC
Molecular Formula
C27H20O12
Molecular Weight
536.44
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P405-P501
References & Citations
[1]Goldman ME, et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. Mol Pharmacol. 1990;38 (1) :20-25.|[2]Ueno T, et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry. 2000 May 23;39 (20) :5995-6002.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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