β-Rubromycin

• Description :

  β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a Ki of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC50 of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC50 values of 19.5 µM and 22.7 µM, respectively[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302+H312-H319-H351

• Target :

  Bacterial; HIV; Reverse Transcriptase; Telomerase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/β-rubromycin.html

• Purity :

  97.7

• Solubility :

  DMSO : 1 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C(O1)=CC(C=C(CC[C@@]2(OC(C3=O)=C(C(C4=C3C(O)=C(OC)C=C4OC)=O)C2)O5)C5=C6O)=C6C1=O)OC

• Molecular Formula :

  C27H20O12

• Molecular Weight :

  536.44

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P405-P501

• References & Citations :

  [1]Goldman ME, et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. Mol Pharmacol. 1990;38 (1) :20-25.|[2]Ueno T, et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry. 2000 May 23;39 (20) :5995-6002.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HIV-1

• CAS Number :

  [27267-70-5]