Products for Research Use Only
RegisterLogin

Senicapoc

CAT: 0931-T3528-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T3528-02Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
289656-45-7
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.995
Bioactivity
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.
Smiles
NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Molecular Formula
C20H15F2NO
Molecular Weight
323.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Senicapoc

Senicapoc is an orally bioavailable inhibitor of the calcium-activated potassium channel KCa3.1 (Gardos channel; KCNN4; IK-1; SK4), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, senicapoc targets, binds to and inhibits KCa3.1.

CAS Number289656-45-7
PubChem CID216327
IUPAC Name2,2-bis(4-fluorophenyl)-2-phenylacetamide
Molecular FormulaC20H15F2NO
Molecular Weight323.3
XLogP4.1
Topological Polar Surface Area43.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity397
SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
InChI
InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey
SCTZUZTYRMOMKT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Senicapoc
CAS: 289656-45-7
CID: 216327
Formula: C20H15F2NO
MW: 323.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass323.11217043
Monoisotopic Mass323.11217043
Topological Polar Surface Area43.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6866-10Senicapoc
CS-O-63473Senicapoc-d4
HY-50694R-01Senicapoc (Standard)
MBS386855-01Senicapoc (ICA-17043)
A11568-50Senicapoc (ICA-17043) 50mg
A11568-10Senicapoc (ICA-17043) 10mg
A11568-5Senicapoc (ICA-17043) 5mg
BS300121Senicapoc - Bio-X TM
A11568-200Senicapoc (ICA-17043) 200mg
A11568-100Senicapoc (ICA-17043) 100mg

Popular Products