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Senicapoc

CAT: 0931-T3528-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T3528-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
289656-45-7
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.995
Bioactivity
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.
Smiles
NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Molecular Formula
C20H15F2NO
Molecular Weight
323.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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A11568-200Senicapoc (ICA-17043) 200mg
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