Lys05

• Target:

  Lysosomal Autophagy|||Autophagy

• Related Pathways:

  Autophagy

• Purity:

  0.9955

• Bioactivity:

  Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.

• Smiles:

  Cl.Cl.Cl.CN(CCNc1ccnc2cc(Cl)ccc12)CCNc1ccnc2cc(Cl)ccc12

• Molecular Formula:

  C23H26Cl5N5

• Molecular Weight:

  549.75

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1391426-24-6