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L-760735

CAT: 0804-HY-108481-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108481-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects[1].
CAS Number
188923-01-5
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-760735.html
Purity
99.9
Solubility
DMSO : 30.60 mg/mL (ultrasonic; warming)
Smiles
C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OCC2)[C@@](C3=CC=C(C=C3)F)([H])N2CC4=C(N=NN4)CN(C)C.Cl
Molecular Formula
C26H29ClF7N5O2
Molecular Weight
611.98
References & Citations
[1]Harrison T, et al. An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J Med Chem. 2001 Nov 22;44 (24) :4296-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R

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