Niraparib hydrochloride

• Target:

  PARP|||Apoptosis

• Related Pathways:

  DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic

• Purity:

  0.9985

• Bioactivity:

  Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.

• Smiles:

  C (N) (=O) C=1C=2C (=CN (N2) C3=CC=C (C=C3) [C@@H]4CCCNC4) C=CC1.Cl

• Molecular Formula:

  C19H21ClN4O

• Molecular Weight:

  356.85

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1038915-64-8