MSC 2032964A

• Target:

  ASK|||p38 MAPK|||MAPK

• Related Pathways:

  MAPK|||Apoptosis

• Purity:

  >99.99%

• Bioactivity:

  MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.

• Smiles:

  FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1

• Molecular Formula:

  C16H13F3N6O

• Molecular Weight:

  362.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1124381-43-6