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AKT inhibitor VIII

CAT: 0931-T3346-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T3346-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
612847-09-3
Target
Apoptosis, Akt
Related Pathways
PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis
Purity
0.9877
Bioactivity
AKT inhibitor VIII (AKTi-1/2) is a highly specific inhibitor of Akt1/2, with IC50 values of 58 nM and 210 nM respectively, demonstrating approximately 36-fold greater selectivity for Akt1 over Akt3.
Smiles
O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1
Molecular Formula
C34H29N7O
Molecular Weight
551.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Akt inhibitor VIII

3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]-4-piperidinyl]-1H-benzimidazol-2-one is a member of piperidines.

CAS Number612847-09-3
PubChem CID135398501
IUPAC Name3-[1-[[4-(6-phenyl-8H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one
Molecular FormulaC34H29N7O
Molecular Weight551.6
XLogP4.3
Topological Polar Surface Area84.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count42
Formal Charge0
Complexity1270
SMILES
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=C(N=C6C=C7C(=NC=N7)C=C6N5)C8=CC=CC=C8
InChI
InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25,38H,14-17,20H2,(H,39,42)
InChIKey
IWCQHVUQEFDRIW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Akt inhibitor VIII
CAS: 612847-09-3
CID: 135398501
Formula: C34H29N7O
MW: 551.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight551.6
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass551.24335857
Monoisotopic Mass551.24335857
Topological Polar Surface Area84.7 Ų
Heavy Atom Count42
Formal Charge0
Complexity1270
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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