GSK321

• Target:

  Dehydrogenase|||Isocitrate Dehydrogenase (IDH)

• Related Pathways:

  Metabolism

• Purity:

  0.9973

• Bioactivity:

  GSK321 is a selective and potent mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that inhibits lipid synthesis and blocks cell proliferation in OPA1-deficient MEFs and prevents cytoplasmic glutamine reductive carboxylation.GSK321 has been used in the study of leukemia.

• Smiles:

  C(N1C2=C(C(C(NC3=CC([C@H](C)O)=CC=C3)=O)=N1)CN(C(=O)C4=CC=CN4)C[C@H]2C)C5=CC=C(F)C=C5

• Molecular Formula:

  C28H28FN5O3

• Molecular Weight:

  501.55

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1816331-63-1