NS-1619

CAT: 0931-T3102-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T3102-01Size:1 mg

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CAS Number

153587-01-0

Target

Apoptosis, Potassium Channel

Related Pathways

Apoptosis, Membrane transporter/Ion channel

Purity

0.9828

Bioactivity

NS1619 have cardio-protective effects after ischemia-reperfusion injury.

Smiles

Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F

Molecular Formula

C15H8F6N2O2

Molecular Weight

362.23

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

1,3-dihydro-1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-2H-benzimidazol-2-one

NS 1619 is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca). It has a role as a potassium channel opener. It is a member of benzimidazoles, a member of phenols and a member of (trifluoromethyl)benzenes.

CAS Number	153587-01-0
PubChem CID	4552
IUPAC Name	3-[2-hydroxy-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1H-benzimidazol-2-one
Molecular Formula	C15H8F6N2O2
Molecular Weight	362.23
XLogP	3.7
Topological Polar Surface Area	52.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	1
Heavy Atom Count	25
Formal Charge	0
Complexity	523

SMILES

C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)C(F)(F)F)O

InChI

InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)

InChIKey

YLFMCMWKHSDUCT-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 153587-01-0

CID: 4552

Formula: C15H8F6N2O2

MW: 362.23

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	362.23
XLogP3	3.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	1
Exact Mass	362.04899647
Monoisotopic Mass	362.04899647
Topological Polar Surface Area	52.6 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	523
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T31608	EIDD-1619
T71486-01	NS-0011
T33734-01	NS 11
T16344-01	NS-2028
T4294-01	NS 11021
T38779-01	NS-102
T28196-01	NS-220
T33735-01	NS-1231
T23088-01	NS 3763
T73572-01	NS-8

Alternative Products

Catalog	Name
B1303-5	NS-1619
GTR19163063-01	NS 1619
HY-12496R-01	NS-1619 (Standard)
TBI4643-5MG	NS 1619, Selective KCa1.1 activator
GTR19194589	EIDD-1619

NS-1619

Chemical Information

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