AKB-6899

• CAS Number :

  1007377-55-0

• Target :

  HIF/HIF Prolyl-Hydroxylase|||VEGFR|||HIF

• Related Pathways :

  Chromatin/Epigenetic|||Angiogenesis|||Metabolism|||Tyrosine Kinase/Adaptors

• Purity :

  0.9787

• Bioactivity :

  AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2? which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.

• Smiles :

  OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(F)c1

• Molecular Formula :

  C14H11FN2O4

• Molecular Weight :

  290.25

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C