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Bardoxolone

CAT: 0931-T2915-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T2915-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
218600-44-3
Target
SARS-CoV|||Necroptosis|||Nrf2|||Virus Protease
Related Pathways
Microbiology/Virology|||Immunology/Inflammation|||Apoptosis
Purity
0.9919
Bioactivity
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-?-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis. In various Y cell lines, Bardoxolone has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that Bardoxolone is a ligand for peroxisome proliferator-activated receptor ?, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.
Smiles
CC1(C)CC[C@@]2(CC[C@]3(C)[C@@H]([C@H]2C1)C(=O)C=C1[C@@]2(C)C=C(C#N)C(=O)C(C)(C)C2CC[C@@]31C)C(O)=O
Molecular Formula
C31H41NO4
Molecular Weight
491.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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