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Cantharidic acid

CAT: 0804-HY-137135Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-137135Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1) . Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway[1].
CAS Number
28874-45-5
UNSPSC
12352005
Hazard Statement
H315
Target
Apoptosis; ERK; JNK; p38 MAPK; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cantharidic-acid.html
Smiles
OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
Molecular Formula
C10H14O5
Molecular Weight
214.22
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Chen YC, et al., Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35 (5) :619-627.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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