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Ticolubant

CAT: 0931-T28974-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T28974-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
154413-61-3
Target
Leukotriene Receptor, Calcium Channel, LTR
Related Pathways
Membrane transporter/Ion channel, GPCR/G Protein, Immunology/Inflammation, Metabolism
Purity
0.9959
Bioactivity
Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
Smiles
C(=C/C(O)=O)\C1=C(OCCC2=CC=CC=C2)C=CC(CSC3=C(Cl)C=CC=C3Cl)=N1
Molecular Formula
C23H19Cl2NO3S
Molecular Weight
460.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19196320-01Ticolubant

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