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Tenofovir exalidex

CAT: 0931-T28946-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T28946-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
911208-73-6
Target
HBV, Nucleoside Antimetabolite/Analog, Antiviral, HIV Protease
Related Pathways
DNA Damage/DNA Repair, Immunology/Inflammation, Microbiology/Virology, Proteases/Proteasome, Cell Cycle/Checkpoint
Purity
0.9983
Bioactivity
Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleoside/nucleotide analogs. It effectively inhibits all major HIV-1 and HIV-2 subtypes in fresh human PBMCs, as well as all evaluated HIV-1 strains in monocyte-derived macrophages, displaying EC50 values between 0.2 and 7.2 nM. Oral administration of CMX157 shows no apparent toxicity. Additionally, Tenofovir exalidex exhibits antiviral properties against HBV.
Smiles
C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)C)N1C=2C(N=C1)=C(N)N=CN2
Molecular Formula
C28H52N5O5P
Molecular Weight
569.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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