SUN-C5174

CAT: 0931-MF-0140726-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0140726-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
191592-36-6
Target
Others|||5-HT Receptor
Related Pathways
GPCR/G Protein|||Neuroscience|||Others
Bioactivity
SUN-C5174 is a sleective 5-HT2 antagonist (pA2=8.98+/-0.06) . SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma (IC50=6.5 to 16 nM) . SUN-C5174 significantly inhibited the mortality rate in mouse acute pulmonary thromboembolytic death induced by collagen and serotonin at oral doses of 0.3 mg/kg or higher.
Smiles
CN1C2=C(C(=O)N(CCCN3CCN(CC3)C4=CC=C(F)C=C4)CC[C@@H]2O)C=C1
Molecular Formula
C22H29FN4O2
Molecular Weight
400.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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