PMX-53

• Target:

  Complement System

• Related Pathways:

  Immunology/Inflammation

• Bioactivity:

  PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR (CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-induced hypernociception in rats.

• Smiles:

  CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C1=O

• Molecular Formula:

  C47H65N11O7

• Molecular Weight:

  896.09

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  219639-75-5