Parsaclisib hydrochloride

CAT: 0931-T28297-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T28297-01Size:25 mg

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CAS Number

1995889-48-9

Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Bioactivity

Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.

Smiles

Cl.CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12

Molecular Formula

C20H23Cl2FN6O2

Molecular Weight

469.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Parsaclisib Hydrochloride

Parsaclisib Hydrochloride is the hydrochloride salt form of parsaclisib, an inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.

CAS Number	1995889-48-9
PubChem CID	122507744
IUPAC Name	(4R)-4-[3-[(1S)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one;hydrochloride
Molecular Formula	C20H23Cl2FN6O2
Molecular Weight	469.3
Topological Polar Surface Area	108
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	31
Formal Charge	0
Complexity	632

SMILES

CCOC1=C(C(=C(C=C1[C@H](C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)[C@H]4CC(=O)NC4.Cl

InChI

InChI=1S/C20H22ClFN6O2.ClH/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20;/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26);1H/t10-,11-;/m0./s1

InChIKey

TWHUONANZMKBKX-ACMTZBLWSA-N

Chemical Structure

2D Structure

CAS: 1995889-48-9

CID: 122507744

Formula: C20H23Cl2FN6O2

MW: 469.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	469.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	468.1243575
Monoisotopic Mass	468.1243575
Topological Polar Surface Area	108 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	632
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
VED88948-01	Parsaclisib hydrochloride
HY-109068A-01	Parsaclisib (hydrochloride)
BA8737-5	Parsaclisib
A13561-100	Parsaclisib 100mg
A13561-50	Parsaclisib 50mg
MBS3613556-01	Parsaclisib HCl
A13561-10	Parsaclisib 10mg
A13561-5	Parsaclisib 5mg
A13561-25	Parsaclisib 25mg
C01085-01	Parsaclisib (INCB050465)

Parsaclisib hydrochloride

Chemical Information

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