Crocin

• Target :

  Endogenous Metabolite|||Others|||JAK|||Apoptosis

• Related Pathways :

  Angiogenesis|||Others|||Stem Cells|||Chromatin/Epigenetic|||Metabolism|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Apoptosis

• Purity :

  0.9927

• Bioactivity :

  Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L.) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF) alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase.

• Smiles :

  C\C(\C=C\C=C(/C)C(=O)OC1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)=C/C=C/C=C(\C)/C=C/C=C(\C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O

• Molecular Formula :

  C44H64O24

• Molecular Weight :

  976.96

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  42553-65-1