J-104132

CAT: 0931-T27647-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T27647-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

198279-45-7

Target

Others

Related Pathways

Others

Bioactivity

J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of [3H]inositol phosphates in Chinese hamster ovary cells stably expressing cloned human ETA receptors (IC50 = 0.059 nM) . Pretreatment with J-104132 prevents the lethal response to ET-1 when administered i.v. (ED50 = 0.045 mg/kg) or p.o. in fed animals (ED50 = 0.35 mg/kg) .

Smiles

C(O)(=O)[C@H]1[C@@H](C=2C([C@@H]1C=3C=C4C(=CC3)OCO4)=CC=C(CCCC)N2)C5=C(C[C@@H](C(O)=O)C)C=C(OC)C=C5

Molecular Formula

C31H33NO7

Molecular Weight

531.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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