Olorofim

• Target :

  Dehydrogenase|||Antifungal

• Related Pathways :

  Microbiology/Virology|||Metabolism

• Purity :

  0.9928

• Bioactivity :

  Olorofim (F-901318) is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM) .Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.

• Smiles :

  C(C(NC1=CC=C(C=C1)N2CCN(CC2)C=3N=CC(F)=CN3)=O)(=O)C4=C(C=C(C)N4C)C5=CC=CC=C5

• Molecular Formula :

  C28H27FN6O2

• Molecular Weight :

  498.55

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1928707-56-5