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C188

CAT: 0931-T26936Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T26936Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
823828-18-8
Target
Others, Apoptosis, STAT
Related Pathways
Apoptosis, Others, Stem Cells, JAK/STAT signaling
Bioactivity
C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation.
Smiles
OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O
Molecular Formula
C19H15NO7S2
Molecular Weight
433.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid

a STAT3 inhibitor

CAS Number823828-18-8
PubChem CID1652812
IUPAC Name4-[[3-(carboxymethylsulfanyl)-4-hydroxynaphthalen-1-yl]sulfamoyl]benzoic acid
Molecular FormulaC19H15NO7S2
Molecular Weight433.5
XLogP3
Topological Polar Surface Area175
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count29
Formal Charge0
Complexity700
SMILES
C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)C(=O)O
InChI
InChI=1S/C19H15NO7S2/c21-17(22)10-28-16-9-15(13-3-1-2-4-14(13)18(16)23)20-29(26,27)12-7-5-11(6-8-12)19(24)25/h1-9,20,23H,10H2,(H,21,22)(H,24,25)
InChIKey
CIERPRDYPKVDJO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid
CAS: 823828-18-8
CID: 1652812
Formula: C19H15NO7S2
MW: 433.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight433.5
XLogP33
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass433.02899416
Monoisotopic Mass433.02899416
Topological Polar Surface Area175 Ų
Heavy Atom Count29
Formal Charge0
Complexity700
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5776661C188
C13533-01C188-9

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