AR-H067637

• Target:

  Others|||Thrombin

• Related Pathways:

  Proteases/Proteasome|||Others

• Bioactivity:

  AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K (i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total amount of free thrombin generated in platelet-poor clotting plasma was inhibited concentration-dependently by AR-H067637, with a concentration giving half maximal inhibition (IC (50) ) of 0.6 microM. AR-H067637 also inhibited thrombin-induced platelet activation (by glycoprotein IIb/IIIa exposure, IC (50) 8.4 nM) and aggregation (IC (50) 0.9 nM) .

• Smiles:

  C ([C@H] (O) C1=CC (OC (F) F) =CC (Cl) =C1) (=O) N2[C@H] (C (NCC3=CC=C (C (=N) N) C=C3) =O) CC2

• Molecular Formula:

  C21H21ClF2N4O4

• Molecular Weight:

  466.87

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  433937-74-7