Gandotinib

• Target :

  FGFR|||VEGFR|||FLT|||JAK

• Related Pathways :

  Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Stem Cells|||Angiogenesis

• Purity :

  0.9986

• Bioactivity :

  LY2784544 (Gandotinib (LY2784544) ) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F (Ki: 0.245 nM) . The selectivity is higher 8- and 20-fold than JAK1 and JAK3.

• Smiles :

  C(C=1C=2N(C(CC3=C(F)C=C(Cl)C=C3)=C(C)N2)N=C(NC=4C=C(C)NN4)C1)N5CCOCC5

• Molecular Formula :

  C23H25ClFN7O

• Molecular Weight :

  469.94

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1229236-86-5