Masitinib

CAT: 0931-T2609-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0931-T2609-01Size:1 mL - 10 mM (in DMSO)

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

790299-79-5

Target

Src, c-Kit, PDGFR, FAK, c-Fms, Apoptosis, FGFR, Bcr-Abl, Hck

Related Pathways

Cytoskeletal Signaling, Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors

Purity

>99.99%

Bioactivity

Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.

Smiles

N(C1=NC(=CS1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(C)CC5)C=C4)=CC=C3C

Molecular Formula

C28H30N6OS

Molecular Weight

498.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Masitinib

Masitinib is a member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N3-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor. It has a role as an antineoplastic agent, an antirheumatic drug and a tyrosine kinase inhibitor. It is a member of benzamides, a member of pyridines, a member of 1,3-thiazoles and a N-alkylpiperazine.

CAS Number	790299-79-5
PubChem CID	10074640
IUPAC Name	4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
Molecular Formula	C28H30N6OS
Molecular Weight	498.6
XLogP	4.3
Topological Polar Surface Area	102
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	36
Formal Charge	0
Complexity	696

SMILES

CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5

InChI

InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)

InChIKey

WJEOLQLKVOPQFV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 790299-79-5

CID: 10074640

Formula: C28H30N6OS

MW: 498.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	498.6
XLogP3	4.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	498.22018078
Monoisotopic Mass	498.22018078
Topological Polar Surface Area	102 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	696
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BUP14486-01	Masitinib

Masitinib

Chemical Information

Alternative Products

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