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Linifanib

CAT: 0931-T2514-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T2514-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
796967-16-3
Target
PDGFR, c-Kit, VEGFR, FLT, Apoptosis, CSF-1R, Autophagy, c-Fms
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Autophagy, Apoptosis
Purity
0.9929
Bioactivity
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM) . Linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3) .
Smiles
Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Molecular Formula
C21H18FN5O
Molecular Weight
375.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
015580Linifanib
HY-50751G-01Linifanib (GMP)
HY-50751SLinifanib-d4
HY-50751RLinifanib (Standard)
S1003-10mgLinifanib (ABT-869)
SF5368-5mgLinifanib (VEGFR inhibitor)

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