SP-100030

• Target:

  NF-?B

• Related Pathways:

  NF-?B

• Purity:

  0.9979

• Bioactivity:

  SP-100030 is a dual inhibitor of NF-?B and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA) .

• Smiles:

  C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(=O)C=2C(C(F)(F)F)=NC(Cl)=NC2

• Molecular Formula:

  C14H5ClF9N3O

• Molecular Weight:

  437.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  154563-54-9