Products for Research Use Only
RegisterLogin

GW8510

CAT: 0931-T24125-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T24125-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
222036-17-1
Target
DNA/RNA Synthesis, CDK
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9932
Bioactivity
GW8510 is a CDK2 (cell cycle protein-dependent kinase 2) inhibitor and RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 improves cognition and prolongs lifespan, which may be related to the modulation of the expression of cell cycle-related protein p21 and CDK family genes, as well as the improvement of mitochondrial function.
Smiles
O=C1NC=2C=CC=3N=CSC3C2C1=CNC4=CC=C(C=C4)S(=O)(=O)NC5=NC=CC=C5
Molecular Formula
C21H15N5O3S2
Molecular Weight
449.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

GW-8510

4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide is a member of benzenes and a sulfonamide.

CAS Number222036-17-1
PubChem CID3536
IUPAC Name4-[(7-hydroxy-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]-N-pyridin-2-ylbenzenesulfonamide
Molecular FormulaC21H15N5O3S2
Molecular Weight449.5
XLogP3.6
Topological Polar Surface Area157
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity753
SMILES
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=CC3=C(NC4=C3C5=C(C=C4)N=CS5)O
InChI
InChI=1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,25,27H,(H,22,26)
InChIKey
CDNIYBIKHDLGMT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of GW-8510
CAS: 222036-17-1
CID: 3536
Formula: C21H15N5O3S2
MW: 449.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight449.5
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass449.06163170
Monoisotopic Mass449.06163170
Topological Polar Surface Area157 Ų
Heavy Atom Count31
Formal Charge0
Complexity753
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3834-25GW8510

Popular Products