2'-Fluorothymidine

• Description :

  2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2) [1].

• Product Name Alternative :

  2'-​Deoxy-​2'-​fluoro-​5-​Methyluridine

• UNSPSC :

  12352005

• Target :

  Nucleoside Antimetabolite/Analog

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/2-fluorothymidine.html

• Concentration :

  10mM

• Purity :

  99.07

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(C(C)=C2)=O)=O)O1

• Molecular Formula :

  C10H13FN2O5

• Molecular Weight :

  260.22

• References & Citations :

  [1]Wiebe LI, et al. Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2) . Curr Radiopharm. 2012 Jan;5 (1) :38-46.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [122799-38-6]