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Motesanib

CAT: 0931-T2288-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T2288-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
453562-69-1
Target
VEGFR, c-Kit
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9909
Bioactivity
Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
Smiles
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
Molecular Formula
C22H23N5O
Molecular Weight
373.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Motesanib

Motesanib is a pyridinecarboxamide.

CAS Number453562-69-1
PubChem CID11667893
IUPAC NameN-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
Molecular FormulaC22H23N5O
Molecular Weight373.5
XLogP3.9
Topological Polar Surface Area78.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity533
SMILES
CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
InChI
InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
InChIKey
RAHBGWKEPAQNFF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Motesanib
CAS: 453562-69-1
CID: 11667893
Formula: C22H23N5O
MW: 373.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight373.5
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass373.19026037
Monoisotopic Mass373.19026037
Topological Polar Surface Area78.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FM65094-01Motesanib
282968-01Motesanib diphosphate

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