EC 144

• Target:

  HSP

• Related Pathways:

  Metabolism|||Cytoskeletal Signaling

• Bioactivity:

  EC 144, a second-generation selective inhibitor of Hsp90 (heat shock protein 90), inhibits tumor growth with an IC50= 1.1 nM for Hsp90? and an EC50 = 14 nM for degradation of Her-2 in MCF-7 cells.

• Smiles:

  ClC1=NC(=NC2=C1C(C#CCC(O)(C)C)=CN2CC3=NC=C(C(OC)=C3C)C)N

• Molecular Formula:

  C21H24ClN5O2

• Molecular Weight:

  413.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  911397-80-3