PF-6274484

• Target :

  EGFR

• Related Pathways :

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity :

  0.9912

• Bioactivity :

  PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

• Smiles :

  COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

• Molecular Formula :

  C18H14ClFN4O2

• Molecular Weight :

  372.78

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1035638-91-5