Products for Research Use Only
RegisterLogin

PF-6274484

CAT: 0013-GTR19172743-01Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19172743-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF-6274484 is a potent, irreversible covalent EGFR kinase inhibitor with a Ki of 0.14 nM. It effectively blocks autophosphorylation of wild-type EGFR and the EGFRL858R/T790M mutant in cellular assays, with IC50 values of 5.8 nM and 6.6 nM, respectively. This inhibitor is a valuable tool for in vitro research in non-small cell lung cancer and resistance mechanism studies.
CAS Number
1035638-91-5
Product Name Alternative
Cysteine, autophosphorylation, kinase, inhibit, HER1, Inhibitor, Epidermal growth factor receptor, ErbB-1, EGFR, signaling, oxidation, PF-6274484, PF6274484, PF 6274484, protein
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.71% (May vary between batches)
Solubility
DMSO:65 mg/mL (174.37 mM)
Smiles
COc1cc2ncnc (Nc3ccc (F) c (Cl) c3) c2cc1NC (=O) C=C
Molecular Formula
C18H14ClFN4O2
Molecular Weight
372.78
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19224314-01PF-06745013
GTR19222974-01PF-06764427
GTR19218956-01PF-07208254
GTR19218556-01PF-07059013
GTR19213053-01PF-17
GTR19212475-01PF-06455943
GTR19211449-01PF-446687
GTR19210318-01PF-4211
GTR19209610-01PF-06658607
GTR19209586-01PF-303

Alternative Products

CatalogName
BA6347-5PF-6274484
MBS3612929-01PF 6274484
MBS579460PF-03084014 (PF-3084014)
BA7029-25PF-04745637
A4374-5.1PF-3845
A8499-50PF-04691502
B8018-100PF 1022A
BA4631-10PF-739
A8320-SPF-00562271
BA6663-5.1PF-06372865

Popular Products