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2-Methoxyestradiol

CAT: 0931-T2220-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
CAT#: T2220-01Size: 1 mL - 10 mM (in DMSO)
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
362-07-2
Target
ROS|||Microtubule Associated|||Endogenous Metabolite|||Autophagy|||Apoptosis|||Reactive Oxygen Species|||HIF
Related Pathways
Angiogenesis|||Immunology/Inflammation|||NF-?B|||Autophagy|||Metabolism|||Cytoskeletal Signaling|||Apoptosis|||Chromatin/Epigenetic
Purity
0.9995
Bioactivity
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
Smiles
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H]
Molecular Formula
C19H26O3
Molecular Weight
302.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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