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AP 18

CAT: 0931-T21543-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T21543-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
55224-94-7
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9996
Bioactivity
AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA) -induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM) .
Smiles
C\C(=C/c1ccc(Cl)cc1)\C(\C)=N\O
Molecular Formula
C11H12ClNO
Molecular Weight
209.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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