AP 18

• Target :

  TRP/TRPV Channel

• Related Pathways :

  Membrane transporter/Ion channel

• Purity :

  0.9996

• Bioactivity :

  AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 ?M Cinnamaldehyde with an IC50 of 3.1 ?M and 4.5 ?M for human and mouse TRPA1, respectively. AP-18 could reverse complete Freund's adjuvant (CFA) -induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 ?M AITC in a concentration-dependent manner (IC50= 10.3 ?M) .

• Smiles :

  C\C(=C/c1ccc(Cl)cc1)\C(\C)=N\O

• Molecular Formula :

  C11H12ClNO

• Molecular Weight :

  209.67

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  55224-94-7