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Cyclosporin H

CAT: 0931-T21493-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T21493-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
83602-39-5
Target
Others
Related Pathways
Others
Purity
0.9994
Bioactivity
Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosporin H is a viral transduction enhancer which increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs) . When combined with Rapamycin or Prostaglandin E2 Cyclosporin H displays an additive effect. Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
Smiles
C\C=C\C[C@H](C)[C@H](O)C1N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)CCCNC1=O)C(C)C
Molecular Formula
C62H111N11O12
Molecular Weight
1202.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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