Fluvastatin

CAT: 0931-T21405-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T21405-01Size:10 mg

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CAS Number

93957-54-1

Target

Autophagy, HMG-CoA Reductase

Related Pathways

Metabolism, Autophagy

Purity

0.9894

Bioactivity

Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction of plasma cholesterol levels and the prevention of cardiovascular disease.

Smiles

C(=C/[C@@H](C[C@@H](CC(O)=O)O)O)\C1=C(C=2C(N1C(C)C)=CC=CC2)C3=CC=C(F)C=C3

Molecular Formula

C24H26FNO4

Molecular Weight

411.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Fluvastatin

Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia. It has a role as an anticholesteremic drug and an EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor. It is a racemate and a statin (synthetic). It contains a (3R,5S)-fluvastatin and a (3S,5R)-fluvastatin.

CAS Number	93957-54-1
PubChem CID	1548972
IUPAC Name	(E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Molecular Formula	C24H26FNO4
Molecular Weight	411.5
XLogP	3.5
Topological Polar Surface Area	82.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Heavy Atom Count	30
Formal Charge	0
Complexity	590

SMILES

CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@@H](C[C@@H](CC(=O)O)O)O)C3=CC=C(C=C3)F

InChI

InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1

InChIKey

FJLGEFLZQAZZCD-JUFISIKESA-N

Chemical Structure

2D Structure

CAS: 93957-54-1

CID: 1548972

Formula: C24H26FNO4

MW: 411.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	411.5
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	411.18458647
Monoisotopic Mass	411.18458647
Topological Polar Surface Area	82.7 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	590
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

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TN10674-01	Fluostatin A
TN7280-01	Fluostatin B
T83863	Fluostatin A sodium

Alternative Products

Catalog	Name
A3419-100	Fluvastatin
A4363-50	Fluvastatin Sodium
A21232-100	Fluvastatin 100mg
A21232-25	Fluvastatin 25mg
A21232-10	Fluvastatin 10mg
bs-82521C-01	Fluvastatin Na

Fluvastatin

Chemical Information

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