Tacrolimus monohydrate

• Target:

  Autophagy|||Phosphatase|||FKBP|||Antibiotic|||Antibacterial

• Related Pathways:

  Apoptosis|||Metabolism|||Immunology/Inflammation|||Autophagy|||Microbiology/Virology

• Purity:

  0.992

• Bioactivity:

  Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo.

• Smiles:

  O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O.O

• Molecular Formula:

  C44H71NO13

• Molecular Weight:

  822.05

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  109581-93-3