Tacrolimus

• Target:

  Antibacterial|||Antibiotic|||Phosphatase|||Autophagy|||mTOR

• Related Pathways:

  Metabolism|||PI3K/Akt/mTOR signaling|||Microbiology/Virology|||Autophagy

• Purity:

  0.9994

• Bioactivity:

  Tacrolimus (FK506, Fujimycin) is a macrolide immunosuppressant that binds to FKBP12 to form a high-affinity complex (Ki = 0.2 nM), which inhibits calcineurin phosphatase activity, thereby suppressing T lymphocyte signal transduction and the transcription and release of IL-2. It exerts potent immunosuppressive effects and can be used to induce immunosuppression models.

• Smiles:

  CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC

• Molecular Formula:

  C44H69NO12

• Molecular Weight:

  804.02

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  104987-11-3