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Tacrolimus

CAT: 0931-T2144-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T2144-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
104987-11-3
Target
Antibacterial, Antibiotic, Phosphatase, Autophagy, mTOR
Related Pathways
Metabolism, PI3K/Akt/mTOR signaling, Microbiology/Virology, Autophagy
Purity
0.9994
Bioactivity
Tacrolimus (FK506, Fujimycin) is a macrolide immunosuppressant that binds to FKBP12 to form a high-affinity complex (Ki = 0.2 nM), which inhibits calcineurin phosphatase activity, thereby suppressing T lymphocyte signal transduction and the transcription and release of IL-2. It exerts potent immunosuppressive effects and can be used to induce immunosuppression models.
Smiles
CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC
Molecular Formula
C44H69NO12
Molecular Weight
804.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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