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Semaxinib

CAT: 0931-T2064-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T2064-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
204005-46-9
Target
VEGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9984
Bioactivity
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.
Smiles
C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C
Molecular Formula
C15H14N2O
Molecular Weight
238.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Semaxinib
CAS Number204005-46-9
PubChem CID123015
IUPAC Name3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Molecular FormulaC15H14N2O
Molecular Weight238.28
XLogP2.5
Topological Polar Surface Area44.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity377
SMILES
CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C
InChI
InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)
InChIKey
WUWDLXZGHZSWQZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Semaxinib
CAS: 204005-46-9
CID: 123015
Formula: C15H14N2O
MW: 238.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight238.28
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass238.110613074
Monoisotopic Mass238.110613074
Topological Polar Surface Area44.9 Ų
Heavy Atom Count18
Formal Charge0
Complexity377
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-10374-01Semaxinib
GTR19173821-01(Z) -Semaxinib
MBS575763Semaxinib(SU 5416)
MBS386234-01SU 5416 (Semaxinib)
A12437-500SU 5416 (Semaxinib) 500mg
A12437-1000SU 5416 (Semaxinib) 1000mg
A12437-100SU 5416 (Semaxinib) 100mg
A12437-50SU 5416 (Semaxinib) 50mg
A12437-25SU 5416 (Semaxinib) 25mg
A12437-10SU 5416 (Semaxinib) 10mg

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