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Semaxinib

CAT: 0931-T2064-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T2064-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
204005-46-9
Target
VEGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9984
Bioactivity
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.
Smiles
C(=C1C=2C(NC1=O)=CC=CC2)C=3NC(C)=CC3C
Molecular Formula
C15H14N2O
Molecular Weight
238.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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