UbcH5c-IN-1

CAT: 0804-HY-103046-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103046-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1].

CAS Number

2123480-72-6

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/UbcH5c-IN-1.html

Purity

99.84

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

BrC1=CC=CC=C1COC2=C(C)C([C@H](OC(C3=C)=O)[C@H]3CC4)=C4C(C)=C2

Molecular Formula

C22H21BrO3

Molecular Weight

413.30

References & Citations

[1]Chen H, et al. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives. J Med Chem. 2017 Aug 24;60 (16) :6828-6852.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

Catalog	Name
T13242-01	UbcH5c-IN-1
A19784-100	UbcH5c-IN-1 100mg
A19784-1	UbcH5c-IN-1 1mg
A19784-50	UbcH5c-IN-1 50mg
A19784-25	UbcH5c-IN-1 25mg
A19784-5	UbcH5c-IN-1 5mg
A19784-10	UbcH5c-IN-1 10mg
MBS517747-01	UBE2D3 (UBCH5C), Active
MBS5304298-01	UBCH5c protein (His tag)
CD00733-01	Recombinant Human UBCH5C protein

UbcH5c-IN-1

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