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Apilimod

CAT: 0931-T2018-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T2018-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
541550-19-0
Target
IL Receptor, PI3K, Interleukin
Related Pathways
PI3K/Akt/mTOR signaling, Immunology/Inflammation
Purity
0.9989
Bioactivity
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
Smiles
Cc1cccc(\C=N\Nc2cc(nc(OCCc3ccccn3)n2)N2CCOCC2)c1
Molecular Formula
C23H26N6O2
Molecular Weight
418.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Apilimod

Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 in IFNg/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs. Apilimod is a potent and highly selective PIKfyve inhibitor.

CAS Number541550-19-0
PubChem CID10173277
IUPAC NameN-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
Molecular FormulaC23H26N6O2
Molecular Weight418.5
XLogP3.8
Topological Polar Surface Area84.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity544
SMILES
CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
InChI
InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
InChIKey
HSKAZIJJKRAJAV-KOEQRZSOSA-N
Chemical Structure
2D Structure
2D structure of Apilimod
CAS: 541550-19-0
CID: 10173277
Formula: C23H26N6O2
MW: 418.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.5
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass418.21172409
Monoisotopic Mass418.21172409
Topological Polar Surface Area84.8 Ų
Heavy Atom Count31
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3840054-01Apilimod
407105Apilimod mesylate

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