Dacomitinib hydrate

• Target :

  EGFR

• Related Pathways :

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity :

  0.9952

• Bioactivity :

  Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

• Smiles :

  O.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1

• Molecular Formula :

  C24H27ClFN5O3

• Molecular Weight :

  487.96

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1042385-75-0