Dacomitinib hydrate

• Target:

  EGFR

• Related Pathways:

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity:

  0.9952

• Bioactivity:

  Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

• Smiles:

  O.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1

• Molecular Formula:

  C24H27ClFN5O3

• Molecular Weight:

  487.96

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1042385-75-0