Dacomitinib

• Target:

  EGFR|||Apoptosis

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Apoptosis

• Purity:

  >99.99%

• Bioactivity:

  Dacomitinib (PF299) (PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

• Smiles:

  COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1

• Molecular Formula:

  C24H25ClFN5O2

• Molecular Weight:

  469.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1110813-31-4