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Dacomitinib

CAT: 0931-T2483-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T2483-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1110813-31-4
Target
EGFR, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Apoptosis
Purity
>99.99%
Bioactivity
Dacomitinib (PF299) (PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
Smiles
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
Molecular Formula
C24H25ClFN5O2
Molecular Weight
469.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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