PF-06273340

• Target:

  Trk receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Purity:

  0.98

• Bioactivity:

  PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM) . PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 x 10 6 cm s 1) .

• Smiles:

  C(=O)(C=1C=2C(N(C(CO)(C)C)C1)=NC(N)=NC2)C=3C=C(NC(CC4=CC=C(Cl)C=N4)=O)C=NC3

• Molecular Formula:

  C23H22ClN7O3

• Molecular Weight:

  479.92

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1402438-74-7