Dabrafenib

• Target:

  Raf

• Related Pathways:

  MAPK

• Purity:

  >99.99%

• Bioactivity:

  Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.

• Smiles:

  CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F

• Molecular Formula:

  C23H20F3N5O2S2

• Molecular Weight:

  519.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1195765-45-7