Dabrafenib

• Target :

  Raf

• Related Pathways :

  MAPK

• Purity :

  >99.99%

• Bioactivity :

  Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.

• Smiles :

  CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F

• Molecular Formula :

  C23H20F3N5O2S2

• Molecular Weight :

  519.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1195765-45-7